Development of Bioreduction Labile Protecting Groups for the 2′-Hydroxyl Group of RNA

Autor:	Kazuma Terasawa, Kodai Nakamura, Akira Ono, Hisao Saneyoshi
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Molecular Structure Hydroxyl Radical Stereochemistry Chemistry Organic Chemistry RNA Biochemistry chemistry.chemical_compound Enzyme Group (periodic table) Nitro Molecule Hydroxyl radical Physical and Theoretical Chemistry Benzene Protecting group
Zdroj:	Organic Letters. 22:6006-6009
ISSN:	1523-7052 1523-7060
DOI:	10.1021/acs.orglett.0c02086
Popis:	Protection and deprotection of the 2'-hydroxyl group of RNAs are critical for RNA-based drug discovery. This paper reports development of a bioreduction labile protecting group of the 2'-hydroxyl group in RNA. After the reduction of the nitro group in a chemical or enzymatic manner, the protecting groups were removed spontaneously. The attachment of electron-donating groups to the benzene ring or benzylic carbon enabled fast and controllable deprotection of the 2'-hydroxyl protecting group under physiological conditions.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74cb204f2cc449ca32cce776f0840bd2 https://doi.org/10.1021/acs.orglett.0c02086 Zobrazit plný text záznamu