Effects of dexamethasone on the development of neonatal rats and level of active caspase-3 in brain cortex
| Autor: | V. V. Muzyka, P. N. Men’shanov, N. N. Dygalo |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
Reflex Startle Time Factors medicine.medical_treatment Caspase 3 General Biochemistry Genetics and Molecular Biology Dexamethasone Internal medicine Active caspase 3 medicine Animals Rats Wistar Glucocorticoids Cerebral Cortex Analysis of Variance Protease business.industry Brain cortex General Medicine Startle reaction Rats Endocrinology medicine.anatomical_structure Animals Newborn Cerebral cortex Apoptosis Immunology Growth and Development business medicine.drug Densitometry |
| Zdroj: | Bulletin of experimental biology and medicine. 153(4) |
| ISSN: | 1573-8221 |
| Popis: | Dexamethasone increased the levels of active caspase-3 form in the brain cortex of neonatal rats 120 h after drug administration, but did not affect the expression of this key apoptotic protease in the brain 6 or 24 h postinjection. Increased expression of the active form of caspase-3 in the cerebral cortex was associated with earlier eye opening and delayed formation of startle-reflex in rats. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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