In vivo antihypertensive mechanism of lactoferrin-derived peptides: Reversion of angiotensin I- and angiotensin II-induced hypertension in Wistar rats
| Autor: | Paloma Manzanares, María Castelló-Ruiz, José V. Gimeno-Alcañiz, Aurora García-Tejedor, Juan B. Salom |
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| Přispěvatelé: | Ministerio de Educación y Ciencia (España), European Commission, Instituto de Salud Carlos III |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
medicine.medical_specialty
Medicine (miscellaneous) Lactoferrin-derived peptides Pharmacology Wistar rat Antihypertensive peptides Internal medicine Renin–angiotensin system Medicine TX341-641 Angiotensin-induced hypertension Nutrition and Dietetics Angiotensin II receptor type 1 biology Nutrition. Foods and food supply business.industry Captopril Angiotensin-converting enzyme Angiotensin II Blood pressure Endocrinology Valsartan biology.protein Renin angiotensin system medicine.symptom business Vasoconstriction Food Science medicine.drug In vivo ACE inhibition |
| Zdroj: | Journal of Functional Foods, Vol 15, Iss, Pp 294-300 (2015) Digital.CSIC. Repositorio Institucional del CSIC instname |
| ISSN: | 2010-2100 |
| Popis: | Novel peptides with antihypertensive effects in SHR rats have previously been identified in lactoferrin (LF) hydrolysates. To investigate their in vivo antihypertensive mechanism, we have assessed the blood pressure lowering effects of two of these LF-derived peptides (RPYL and DPYKLRP) in Wistar rats subjected to either angiotensin I- or angiotensin II-induced hypertension. Blood pressure was measured by the tail-cuff method, hypertension was induced by subcutaneous infusion of angiotensins, and then captopril, valsartan or LF-derived peptides orally administered. Angiotensin I- and angiotensin II-induced hypertension were reversed by captopril and valsartan, respectively. RPYL and DPYKLRP reversed angiotensin I-induced hypertension, while DPYKLRP but not RPYL produced a modest reversion of angiotensin II-elicited hypertension. Neither RPYL nor DPYKLRP modified normotension. Thus, in vivo ACE inhibition is involved in the antihypertensive effects of LF-derived peptides like RPYL and DPYKLRP, while inhibition of AT1 receptor-mediated vasoconstriction plays a less relevant role. This work was supported by grant AGL2010-21009 from ‘Ministerio de Educación y Ciencia – FEDER’, Consolider Ingenio 2010, Fun-C-Food, CSD2007-00063 and RETICS INVICTUS RD12/0014/0004 from ‘Instituto de Salud Carlos III’. A. García-Tejedor is recipient of a predoctoral fellowship from ‘Ministerio de Educación y Ciencia’ (BES-2011-044424). |
| Databáze: | OpenAIRE |
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