Britanin attenuates ovalbumin-induced airway inflammation in a murine asthma model
| Autor: | Eunkyung Lee, Sun-Gun Kim, Kyu-Tae Jeong, Na-Young Park, Meihua Jin, Youn Ju Lee, Eujin Lee, Keuk-Jun Kim, Hyo-Hyun Park |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Ovalbumin Immunoglobulin E 03 medical and health sciences Lactones Mice 0302 clinical medicine Drug Discovery medicine Eosinophilia Animals Inflammation Mice Inbred BALB C Lung medicine.diagnostic_test biology business.industry Organic Chemistry respiratory system Eosinophil Mucus Asthma respiratory tract diseases Disease Models Animal 030104 developmental biology Bronchoalveolar lavage medicine.anatomical_structure 030220 oncology & carcinogenesis Immunology biology.protein Molecular Medicine Methacholine Female medicine.symptom Inflammation Mediators business Sesquiterpenes medicine.drug |
| Zdroj: | Archives of pharmacal research. 39(7) |
| ISSN: | 1976-3786 |
| Popis: | We previously demonstrated the alleviation of ovalbumin (OVA)-induced airway inflammation by Inulae flos. In the present study, the effects of britanin, a sesquiterpene compound isolated from Inulae flos, were evaluated in an in vivo animal model for anti-asthma activity through observation of airway hyperresponsiveness (AHR), eosinophil recruitment, Th2 cytokine and IgE levels, and lung histopathology. Britanin administration effectively reduced AHR induced by aerosolized methacholine, airway eosinophilia, Th2 cytokines in bronchoalveolar lavage fluids and the supernatant of cultured splenocytes compared with OVA-induced mice. Histological studies showed that increased inflammatory cell infiltration and mucus secretion were reduced by britanin administration. Thus, britanin may have therapeutic potential for treating allergic asthma. |
| Databáze: | OpenAIRE |
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