Effect of an acute bout of aerobic exercise on chemerin levels in obese adults
| Autor: | Jill A. Kanaley, Stefan Keslacy, Kristin A. Evans, Kristy M. Zerfass, Jesse William Lloyd, Michael E. Holmstrup |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes Article 03 medical and health sciences 0302 clinical medicine Insulin resistance Diabetes mellitus Internal medicine Internal Medicine medicine Humans Aerobic exercise Chemerin Obesity Exercise computer.programming_language Analysis of Variance biology business.industry sed General Medicine medicine.disease 030104 developmental biology Endocrinology Diabetes Mellitus Type 2 biology.protein Homeostatic model assessment Intercellular Signaling Peptides and Proteins Female Analysis of variance Chemokines Insulin Resistance business computer |
| Zdroj: | Diabetes & Metabolic Syndrome: Clinical Research & Reviews. 10:37-42 |
| ISSN: | 1871-4021 |
| DOI: | 10.1016/j.dsx.2015.04.010 |
| Popis: | Summary Aims Serum chemerin concentrations are elevated in obese individuals and may play a role in type 2 diabetes. Exercise improves insulin sensitivity, which may be related to changes in chemerin. This study explored how an acute bout of aerobic exercise affected chemerin levels in non-diabetic obese adults. Methods Blood samples from 11 obese adults were obtained during two separate conditions: sedentary (SED) and exercise (EX; 60–65% VO2peak). Samples were drawn at baseline, immediately following exercise and hourly for an additional 2 h. ANOVA was used to test for differences in chemerin between conditions. Results Unadjusted analysis showed no difference in overall change (baseline to 2 h post) in chemerin between conditions. During the 2-h post-exercise period, chemerin decreased to 12% below baseline, compared to a 2.5% increase above baseline during that time period on the sedentary day (p = 0.06, difference in post-to-2 h change between conditions). Controlling for homeostatic model assessment of insulin resistance (HOMA-IR), a significant difference existed between EX and SED in the change in chemerin from baseline to 2-h post (p = 0.02). Stratified analyses showed a consistent exercise-induced decrease in chemerin among non-insulin resistant subjects, while chemerin increased during exercise among insulin resistant subjects, and then decreased post-exercise. Conclusion An acute bout of exercise in obese individuals may elicit a drop in chemerin levels during the post-exercise period, and this response may vary based on insulin resistance. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect