Optic nerve involvement of Waldenström’s macroglobulinemia: with autopsy findings
| Autor: | Risa Hashida, Masao Hori, Hiroko Nishida, Mami Hatano, Katsuyuki Obara |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Pathology medicine.medical_specialty Neurology Prednisolone medicine.medical_treatment Central nervous system Autopsy Dermatology Blindness Lymphoplasmacytic Lymphoma Fatal Outcome Antineoplastic Combined Chemotherapy Protocols medicine Humans Lymphocytes Aged Chemotherapy business.industry Cytarabine Macroglobulinemia Optic Nerve General Medicine Magnetic Resonance Imaging Psychiatry and Mental health Methotrexate medicine.anatomical_structure Disease Progression Optic nerve Neurology (clinical) Waldenstrom Macroglobulinemia business medicine.drug |
| Zdroj: | Neurological Sciences. 35:1299-1302 |
| ISSN: | 1590-3478 1590-1874 |
| Popis: | Waldenström's macroglobulinemia (WM) is an indolent chronic lymphoproliferative disorder within the spectrum of lymphoplasmacytic lymphoma (LPL), characterized by a proliferation of plasmacytoid lymphocytes and the production of monoclonal IgM. Although, peripheral neurologic complications commonly occurs due to hyperviscosity in WM, central nervous system (CNS) involvement is very rare. Herein, we present the case of a 67-year-old man who initially presented with progressive visual loss and was diagnosed as WM/LPL with a very aggressive clinical course. He underwent chemotherapy with high dose methotrexate (MTX) plus cytarabine (Ara-C). However, he died and findings of a subsequent autopsy revealed the presence of lymphoplasmacytoid cells in the optic nerve. |
| Databáze: | OpenAIRE |
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