Dietary Supplementation with Monosodium Glutamate Suppresses Chemotherapy-Induced Downregulation of the T1R3 Taste Receptor Subunit in Head and Neck Cancer Patients
| Autor: | Hiroki Ohnishi, Yoshiaki Kitamura, Rie Tsutsumi, Hitoshi Shono, Misako Kawai, Eiji Kondo, Suzuno Watanabe, Chisa Fujimoto, Rina Matsushima, Noriaki Takeda, Kana Beppu, Hideki Matsumoto, Hiroshi Sakaue, Go Sato, Ryo Kanamura, Takahiro Azuma |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Taste Monosodium glutamate T1R3 genes Down-Regulation Antineoplastic Agents Umami Dysgeusia Article Receptors G-Protein-Coupled chemistry.chemical_compound Downregulation and upregulation Tongue Taste receptor Internal medicine Sodium Glutamate medicine Humans TX341-641 Aged Aged 80 and over Nutrition and Dietetics business.industry Nutrition. Foods and food supply monosodium glutamate Chemoradiotherapy Middle Aged Taste Buds medicine.anatomical_structure Endocrinology chemistry Head and Neck Neoplasms Dietary Supplements Female head and neck cancer medicine.symptom business Food Science |
| Zdroj: | Nutrients Nutrients, Vol 13, Iss 2921, p 2921 (2021) Volume 13 Issue 9 |
| ISSN: | 2072-6643 |
| Popis: | (Background) We investigated the effect of dietary supplementation with monosodium glutamate (MSG) on chemotherapy-induced downregulation of the T1R3 taste receptor subunit expression in the tongue of patients with advanced head and neck cancer. (Methods) Patients undergoing two rounds of chemoradiotherapy were randomly allocated to a control or intervention group (dietary supplementation with MSG at 2.7 g/day during the second round of chemotherapy). The relative expression of T1R3, a subunit of both umami and sweet taste receptors, in the tongue was assessed by quantitative polymerase chain reaction analysis. Dysgeusia was assessed with a visual analog scale and daily energy intake was evaluated. (Results) T1R3 expression levels in the tongue, taste sensitivity, and daily energy intake were significantly reduced after the first round of chemotherapy compared with before treatment. Furthermore, these parameters significantly decreased after the second round of chemotherapy, but the extent of decrease was significantly attenuated in the MSG group compared with the control group. (Conclusions) MSG supplementation suppresses chemotherapy-induced dysgeusia, possibly due to the inhibition of the T1R3-containing taste receptor downregulation in the tongue, thereby increasing energy intake in patients with advanced head and neck cancer. |
| Databáze: | OpenAIRE |
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