Genomic Profiling of Circulating Tumor DNA From Cerebrospinal Fluid to Guide Clinical Decision Making for Patients With Primary and Metastatic Brain Tumors
| Autor: | Richard S.P. Huang, James Haberberger, Shakti H. Ramkissoon, Wenya Linda Bi, Pratheesh Sathyan, Lori A. Ramkissoon, Glenn J. Lesser, Roy E. Strowd, Brian M. Alexander, Julia A. Elvin, Kimberly McGregor, Erik A. Williams, Worthy Pegram, Amanda Hemmerich, Eric Allan Severson, Jeffrey S. Ross, James Creeden, Thomas J. Cummings, Claire Edgerly, Jeffrey M. Venstrom, Priti Hegde, Sonika Dahiya, Douglas I. Lin, Charlotte Brown, Prasanth Reddy, Natalie Danziger, Malak Abedalthagafi |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Genomic profiling Central nervous system Brain tumor Review CSF (cerebrospinal fluid) lcsh:RC346-429 03 medical and health sciences 0302 clinical medicine Cerebrospinal fluid Clinical decision making Internal medicine medicine circulating tumor DNA (ctDNA) lcsh:Neurology. Diseases of the nervous system business.industry medicine.disease Primary tumor 030104 developmental biology medicine.anatomical_structure Cell-free fetal DNA Neurology Circulating tumor DNA 030220 oncology & carcinogenesis Neurology (clinical) genomic profiling business metastatic disease brain tumor |
| Zdroj: | Frontiers in Neurology Frontiers in Neurology, Vol 11 (2020) |
| ISSN: | 1664-2295 |
| Popis: | Despite advances in systemic therapies for solid tumors, the development of brain metastases remains a significant contributor to overall cancer mortality and requires improved methods for diagnosing and treating these lesions. Similarly, the prognosis for malignant primary brain tumors remains poor with little improvement in overall survival over the last several decades. In both primary and metastatic central nervous system (CNS) tumors, the challenge from a clinical perspective centers on detecting CNS dissemination early and understanding how CNS lesions differ from the primary tumor, in order to determine potential treatment strategies. Acquiring tissue from CNS tumors has historically been accomplished through invasive neurosurgical procedures, which restricts the number of patients to those who can safely undergo a surgical procedure, and for which such interventions will add meaningful value to the care of the patient. In this review we discuss the potential of analyzing cell free DNA shed from tumor cells that is contained within the cerebrospinal fluid (CSF) as a sensitive and minimally invasive method to detect and characterize primary and metastatic tumors in the CNS. |
| Databáze: | OpenAIRE |
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