Attenuation of age-elevated blood factors by repositioning plasmapheresis: A novel perspective and approach
| Autor: | Cameron Kato, Dobri D. Kiprov, Irina M. Conboy, Jessy Etienne, Chao Liu, Michael J. Conboy, Taha Mehdipour, Melod Mehdipour |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
business.industry
medicine.medical_treatment Age Factors Inflammation Plasmapheresis Hematology 030204 cardiovascular system & hematology Bioinformatics Elevated blood Mice 03 medical and health sciences Blood 0302 clinical medicine Animals Humans Medicine Therapeutic plasma exchange Stem cell Signal transduction medicine.symptom Functional decline business Tissue homeostasis 030215 immunology |
| Zdroj: | Transfusion and Apheresis Science. 60:103162 |
| ISSN: | 1473-0502 |
| DOI: | 10.1016/j.transci.2021.103162 |
| Popis: | Aging is associated with the impairment of stem cell activation, leading to the functional decline of tissues and increasing the risk for age-associated diseases. The old, damaged or unrepaired tissues disturb distant tissue homeostasis by secreting factors into the circulation, which may not only serve as biomarkers for specific age-associated pathologies but also induce a variety of degenerative phenotypes. In this review, we summarize and discuss systemic determinants that perpetuate age-related tissue dysfunction. We further elaborate on the effects of attenuating these circulating factors by highlighting recent advances which utilize plasmapheresis in a pre-clinical or clinical setting. Overall, we postulate that repositioning therapeutic plasma exchange (TPE) to dilute the systemic factors, which become deleterious at their age-elevated levels, could be a rapidly effective rejuvenation therapy that recalibrates crucial signaling pathways to a youthful state. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect