Progressive interstitial renal fibrosis due to Chinese herbs in a patient with calcinosis Raynaud esophageal sclerodactyly telangiectasia (CREST) syndrome
| Autor: | Masako Hara, Naoyuki Kamatani, Hiroshi Kajiyama, Chihiro Terai, Emi Nishimagi, Yasushi Kawaguchi |
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| Rok vydání: | 2001 |
| Předmět: |
CREST Syndrome
Pathology medicine.medical_specialty Biopsy complex mixtures Nephropathy Calcinosis Internal Medicine medicine Renal fibrosis Humans Chromatography High Pressure Liquid Kidney medicine.diagnostic_test business.industry Sclerodactyly General Medicine DNA Middle Aged Phenanthrenes medicine.disease Fibrosis medicine.anatomical_structure Disease Progression Aristolochic Acids Nephritis Interstitial Female Renal biopsy medicine.symptom business Kidney disease Drugs Chinese Herbal Mutagens |
| Zdroj: | Internal medicine (Tokyo, Japan). 40(10) |
| ISSN: | 0918-2918 |
| Popis: | A 58-year-old woman with calcinosis Raynaud esophageal sclerodactyly telangiectasia (CREST) syndrome presented with slowly progressive renal dysfunction. She was normotensive with normal plasma renin activity and lacking symptoms of vasculitis. Mild proteinuria was of tubular origin, but serological tests and an absence of sicca symptoms excluded the possibility of Sjogren's syndrome. Light microscopic study of renal biopsy showed interstitial fibrosis with ectasia and degeneration of proximal tubule and lymphocyte infiltration. There were no remarkable changes in the glomeruli. Chromatographic analysis of the Chinese herbs regimen that she had been taking for several years demonstrated aristolochic acid. She was diagnosed as Chinese herbs nephropathy. Therapy with oral prednisolone was markedly effective in improving renal function and anemia. To our knowledge, this is the first report of Chinese herbs nephropathy complicating connective tissue disease. It is important to consider the possibility of Chinese herbs nephropathy when patients treated with Chinese herbs develop renal dysfunction. |
| Databáze: | OpenAIRE |
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