Follow-Up Investigations of Tau Protein and S-100B Levels in Cerebrospinal Fluid of Patients with Creutzfeldt-Jakob Disease
| Autor: | Mirko Bibl, Sigrid Poser, Jens Wiltfang, Walter J. Schulz-Schaeffer, Lukas Cepek, Barbara Ciesielczyk, Markus Otto, Birgitt Wiese, Hans A. Kretzschmar, Petra Steinacker, Inga Zerr, Brit Mollenhauer |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
Pathology animal diseases Disease Creutzfeldt-Jakob Syndrome 0302 clinical medicine Degenerative disease Cerebrospinal fluid Neoplasms Aged 80 and over 0303 health sciences biology S100 Proteins Neurodegenerative Diseases Middle Aged 3. Good health Psychiatry and Mental health Encephalitis Female Adult medicine.medical_specialty Cognitive Neuroscience Medizinische Fakultät -ohne weitere Spezifikation Tau protein tau Proteins S100 Calcium Binding Protein beta Subunit Central nervous system disease Diagnosis Differential 03 medical and health sciences Alzheimer Disease mental disorders medicine Dementia Humans Nerve Growth Factors ddc:610 030304 developmental biology Aged Uremia Epilepsy business.industry medicine.disease nervous system diseases Hepatic Encephalopathy biology.protein Geriatrics and Gerontology business 030217 neurology & neurosurgery Biomarkers Follow-Up Studies |
| Popis: | Background: S-100B and tau protein have a high differential diagnostic potential for the diagnosis of Creutzfeldt-Jakob disease (CJD). So far there has been only limited information available about the dynamics of these parameters in the cerebrospinal fluid (CSF). However, there is a special interest in finding biochemical markers to monitor disease progression for differential diagnosis and treatment. Patients and Methods: We analyzed CSF of 45 patients with CJD and of 45 patients with other neurological diseases for tau protein and S-100B in a follow-up setting. All diagnoses of CJD were later neuropathologically verified. A ratio between tau protein differences and the time between lumbar puncture was calculated. The same was done for S-100B. Results: Tau protein levels of 34 cases were above the cut-off level for CJD (>1,300 pg/ml) in the first CSF sample. In 7 of 11 patients with lower tau levels in the first CSF sample, tau levels rose. The above-mentioned ratio was significantly higher in the CJD group than in the group with other neurological diseases. Similar results were obtained for S-100B. Conclusion: We conclude that follow-up investigations and calculation of ratios is a useful tool in the differential diagnosis of CJD. Variations in this pattern were observed in single cases. |
| Databáze: | OpenAIRE |
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