Axillary lymph-node metabolic activity assessment on 18F-FDG-PET/CT in rheumatoid arthritis patients treated with biologic therapies
| Autor: | Hiroyasu Tomonaga, Takahito Nakajima, Yoshito Tsushima, LD Vu, Yukio Yonemoto, Yukiko Arisaka, Tsuyoshi Tajika, Trang Thuy Dam, Koichi Okamura, Hirotaka Chikuda, Masahiro Tachibana, Takahito Suto |
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| Rok vydání: | 2019 |
| Předmět: |
030203 arthritis & rheumatology
Oncology musculoskeletal diseases medicine.medical_specialty business.industry Immunology Biologic therapies General Medicine medicine.disease 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Rheumatology Rheumatoid arthritis Internal medicine medicine Immunology and Allergy Fdg pet ct 030212 general & internal medicine Lymph Metabolic activity business Lymph node |
| DOI: | 10.6084/m9.figshare.9933167 |
| Popis: | Objective: Recent studies have provided new insights into the role of lymph nodes (LNs) in rheumatoid arthritis (RA). The aim of this study was to evaluate the metabolic activity of the axillary LNs in relation to that of the upper limb joints and the clinical assessment of disease activity in RA patients treated with biologic therapies. Method: 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) scans were acquired for 64 patients with RA at baseline and after 6 months of biologic therapy, and the patients’ clinical status was evaluated. The maximum standardized uptake value (SUVmax), metabolic active volume, and total lesion glycolysis (TLG) were used to assess glucose metabolism in the LNs and 12 joints. Clinical evaluations included serum markers and the Disease Activity Score based on 28-joint count–erythrocyte sedimentation rate (DAS28-ESR). Results: Changes in the SUVmax and TLG for the axillary LNs correlated significantly with those of the ipsilateral wrist joints. There was a positive correlation between the changes in the three metabolic parameters of the axillary LNs and the changes in disease activity after treatment. After 6 months of biologic therapy, all metabolic parameters for the axillary LNs in patients with a DAS28-ESR Conclusion: A relationship between the glucose metabolism of the axillary LNs and the ipsilateral wrist joints was demonstrated by the 18F-FDG-PET/CT parameters. The metabolic activity and active volume of axillary LNs may reflect the therapeutic response to the biologic treatment of RA. |
| Databáze: | OpenAIRE |
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