The rTS signaling pathway as a target for drug development
| Autor: | Bruce J. Dolnick |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Genetics
Messenger RNA Cell signaling biology Gastroenterology RNA Down-Regulation Antineoplastic Agents Thymidylate Synthase behavioral disciplines and activities Thymidylate synthase Recombinant Proteins Antisense RNA Cell biology Oncology Downregulation and upregulation Neoplasms biology.protein Humans RNA Antisense RNA Messenger Signal transduction Gene Signal Transduction |
| Zdroj: | Clinical colorectal cancer. 5(1) |
| ISSN: | 1533-0028 |
| Popis: | The rTS gene was discovered because it codes for a complementary (antisense) RNA to the messenger RNA for thymidylate synthase (TS). It was later shown that rTS also encodes 2 proteins, rTSα and rTβ. Recently, it has become apparent that rTβ overexpression can cause the downregulation of TS protein in a colon cancer cell line through the production of ≥ 1 previously unknown signaling molecules. This observation signified the presence of a previously unidentified signaling pathway. The existence of a signaling pathway that can regulate TS protein levels and the widespread expression of the rTβ protein suggests that a new target for drug development may be on the horizon. This review describes the relationship between the rTS and TS genes and the known and potential effects of rTS RNAs and rTS proteins. We also present the structure of an identified TS downregulatory compound that may serve as a lead compound for development. |
| Databáze: | OpenAIRE |
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