Asparaginase II of Saccharomyces cerevisiae: selection of four mutations that cause derepressed enzyme synthesis
| Autor: | J. Q. Kamerud, Robert J. Roon |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Genetics
chemistry.chemical_classification Mutation Asparaginase Catabolism Nitrogen Glutamate dehydrogenase Saccharomyces cerevisiae Biology medicine.disease_cause biology.organism_classification Microbiology Yeast chemistry.chemical_compound Enzyme chemistry Biochemistry Biosynthesis Glutamate Dehydrogenase medicine Molecular Biology Research Article |
| Zdroj: | Journal of bacteriology. 165(1) |
| ISSN: | 0021-9193 |
| Popis: | A positive selection method was used to isolate four Saccharomyces cerevisiae mutations that cause derepressed synthesis of asparaginase II. The four mutations (and1, and2, and3, and4) were neither closely linked to each other nor linked to previously characterized mutations (asp3, asp6) which cause the complete loss of asparaginase II activity. One of the new mutations (and4) was shown to be allelic to gdh-CR, a pleiotropic mutation which causes derepressed synthesis of a number of enzymes of nitrogen catabolism. |
| Databáze: | OpenAIRE |
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