Crimean-Congo haemorrhagic fever (CCHF) virus-specific antibody detection in blood donors, Castile-León, Spain, summer 2017 and 2018

Autor: Nuria Leralta, María Paz Sánchez Seco, Roger Hewson, Montserrat Alonso Sardón, Fernando de Ory Manchón, Ana Jiménez del Bianco, María Belén Vicente Santiago, Rufino Alamo-Sanz, Sonia Pérez González, Ana Isabel Negredo, Moncef Belhassen-García, Isabel Bas, Juan Luis Muñoz Bellido, Lydia Blanco Peris, María Carmen Vieira Lista, Pedro Fernández Soto, Lía Monsalve Arteaga, Antonio Muro
Přispěvatelé: Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF)
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Veterinary medicine
Epidemiology
Blood Donors
emerging diseases
Antibodies
Viral
viral haemorrhagic fever
Laboratory
0302 clinical medicine
Ticks
Seroepidemiologic Studies
Tick-borne diseases
030212 general & internal medicine
Animal Husbandry
Crimean-Congo haemorrhagic fever
Tick-borne disease
biology
Emerging diseases
Middle Aged
Specific antibody
Hemorrhagic Fever Virus
Crimean-Congo
epidemiology
Female
Antibody
medicine.symptom
Adult
medicine.medical_specialty
Blood donor
tick-borne diseases
re-emerging diseases
Enzyme-Linked Immunosorbent Assay
Asymptomatic
Virus
03 medical and health sciences
Virology
CCHF
medicine
Animals
Humans
CCHF VIRUS
blood donor
Viral haemorrhagic fever
Aged
Re-emerging diseases
business.industry
Research
Public Health
Environmental and Occupational Health
medicine.disease
030104 developmental biology
Cross-Sectional Studies
Spain
biology.protein
Hemorrhagic Fever
Crimean
business
laboratory
Zdroj: Eurosurveillance
Repisalud
Instituto de Salud Carlos III (ISCIII)
ISSN: 1560-7917
1025-496X
Popis: Background Crimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging or even a probable re-emerging pathogen in southern Europe. Presence of this virus had been reported previously in Spain in 2010. Aim We aimed to evaluate the potential circulation of CCHFV in western Spain with a serosurvey in asymptomatic adults (blood donors). Methods During 2017 and 2018, we conducted a CCHFV serosurvey in randomly selected asymptomatic blood donors from western Spain. Three assays using specific IgG antibodies against CCHFV were performed: the VectoCrimea ELISA test, an in-house ELISA and indirect immunofluorescence (EuroImmun) test with glycoprotein and nucleoprotein. Results A total of 516 blood donors participated in this cross-sectional study. The majority of the study participants were male (68.4%), and the mean age was 46.3 years. Most of the participants came from rural areas (86.8%) and 68.6% had contact with animals and 20.9% had animal husbandry practices. One in five participants (109/516, 21.1%) were engaged in at-risk professional activities such as agriculture and shepherding, slaughtering, hunting, veterinary and healthcare work (mainly nursing staff and laboratory technicians). A total of 15.3% of the participants were bitten by ticks in the days or months before the date of sampling. We detected anti-CCHFV IgG antibodies with two diagnostic assays in three of the 516 individuals and with one diagnostic assay in six of the 516 individuals. Conclusion Seroprevalence of CCHFV was between 0.58% and 1.16% in Castile-León, Spain. This is the first study in western Spain that showed circulation of CCHFV in healthy people.
Databáze: OpenAIRE
Externí odkaz: