Crimean-Congo haemorrhagic fever (CCHF) virus-specific antibody detection in blood donors, Castile-León, Spain, summer 2017 and 2018
Autor: | Nuria Leralta, María Paz Sánchez Seco, Roger Hewson, Montserrat Alonso Sardón, Fernando de Ory Manchón, Ana Jiménez del Bianco, María Belén Vicente Santiago, Rufino Alamo-Sanz, Sonia Pérez González, Ana Isabel Negredo, Moncef Belhassen-García, Isabel Bas, Juan Luis Muñoz Bellido, Lydia Blanco Peris, María Carmen Vieira Lista, Pedro Fernández Soto, Lía Monsalve Arteaga, Antonio Muro |
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Přispěvatelé: | Instituto de Salud Carlos III, Unión Europea. Fondo Europeo de Desarrollo Regional (FEDER/ERDF) |
Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
0301 basic medicine
Male Veterinary medicine Epidemiology Blood Donors emerging diseases Antibodies Viral viral haemorrhagic fever Laboratory 0302 clinical medicine Ticks Seroepidemiologic Studies Tick-borne diseases 030212 general & internal medicine Animal Husbandry Crimean-Congo haemorrhagic fever Tick-borne disease biology Emerging diseases Middle Aged Specific antibody Hemorrhagic Fever Virus Crimean-Congo epidemiology Female Antibody medicine.symptom Adult medicine.medical_specialty Blood donor tick-borne diseases re-emerging diseases Enzyme-Linked Immunosorbent Assay Asymptomatic Virus 03 medical and health sciences Virology CCHF medicine Animals Humans CCHF VIRUS blood donor Viral haemorrhagic fever Aged Re-emerging diseases business.industry Research Public Health Environmental and Occupational Health medicine.disease 030104 developmental biology Cross-Sectional Studies Spain biology.protein Hemorrhagic Fever Crimean business laboratory |
Zdroj: | Eurosurveillance Repisalud Instituto de Salud Carlos III (ISCIII) |
ISSN: | 1560-7917 1025-496X |
Popis: | Background Crimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging or even a probable re-emerging pathogen in southern Europe. Presence of this virus had been reported previously in Spain in 2010. Aim We aimed to evaluate the potential circulation of CCHFV in western Spain with a serosurvey in asymptomatic adults (blood donors). Methods During 2017 and 2018, we conducted a CCHFV serosurvey in randomly selected asymptomatic blood donors from western Spain. Three assays using specific IgG antibodies against CCHFV were performed: the VectoCrimea ELISA test, an in-house ELISA and indirect immunofluorescence (EuroImmun) test with glycoprotein and nucleoprotein. Results A total of 516 blood donors participated in this cross-sectional study. The majority of the study participants were male (68.4%), and the mean age was 46.3 years. Most of the participants came from rural areas (86.8%) and 68.6% had contact with animals and 20.9% had animal husbandry practices. One in five participants (109/516, 21.1%) were engaged in at-risk professional activities such as agriculture and shepherding, slaughtering, hunting, veterinary and healthcare work (mainly nursing staff and laboratory technicians). A total of 15.3% of the participants were bitten by ticks in the days or months before the date of sampling. We detected anti-CCHFV IgG antibodies with two diagnostic assays in three of the 516 individuals and with one diagnostic assay in six of the 516 individuals. Conclusion Seroprevalence of CCHFV was between 0.58% and 1.16% in Castile-León, Spain. This is the first study in western Spain that showed circulation of CCHFV in healthy people. |
Databáze: | OpenAIRE |
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