New Taxane Analogues from the Needles of Taxus canadensis

Autor:	Xiao-Li You, Francoise Sauriol, Orval Mamer, Moulay Alaoui-Jamali, Junzeng Zhang, Lolita O. Zamir, Gerald Batist
Rok vydání:	2001
Předmět:	Magnetic Resonance Spectroscopy Stereochemistry Pharmaceutical Science Breast Neoplasms Tumor cells Adenocarcinoma Spectrometry Mass Fast Atom Bombardment Trees Analytical Chemistry chemistry.chemical_compound Alkaloids Drug Discovery Tumor Cells Cultured Taxus canadensis Humans Pharmacology Taxane Molecular Structure biology Organic Chemistry biology.organism_classification Complementary and alternative medicine chemistry Taxus Molecular Medicine Drug Screening Assays Antitumor Diterpene
Zdroj:	Journal of Natural Products. 64:450-455
ISSN:	1520-6025 0163-3864
Popis:	Eight minor taxanes have been identified for the first time in Taxus canadensis needles. Four of these metabolites are new taxane analogues: 7-acetyl-10-deacetyltaxol (1), 2'-acetyl-7-epi-cephalomannine (2), 10-deacetyl-10-oxo-7-epi-cephalomannine (3), and 10-acetylglycollylbaccatin VI (4).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74b672a297dad244e19c358b8aa4fc77 https://doi.org/10.1021/np0004449 Zobrazit plný text záznamu