Cervical cytology in folic acid deficiency of pregnancy
| Autor: | David Z. Kitay, W B Wentz |
|---|---|
| Rok vydání: | 1969 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Time Factors Cell Uterine Cervical Neoplasms Physiology Cervix Uteri Disease Folic Acid Deficiency Serum folate Pregnancy Cytology medicine Humans Subclinical infection Vaginal Smears Clinical Trials as Topic business.industry Obstetrics and Gynecology Cervical cytology medicine.disease Pregnancy Complications medicine.anatomical_structure Folic acid Female business Precancerous Conditions |
| Zdroj: | American Journal of Obstetrics and Gynecology. 104:931-938 |
| ISSN: | 0002-9378 |
| DOI: | 10.1016/0002-9378(69)90682-6 |
| Popis: | Abnormal cervical cytology was discovered among pregnant women demonstrating deficient levels of serum folate, neutrophil hypersegmentation, and megaloblastic bone marrow maturation. In a double blind evaluation, the abnormal cells were not seen on smears acquired from a control group of normal pregnant patients. Cytologic preparations obtained later in the developing deficiency state had a greater chance of showing abnormal cytology. Therefore, this cellular change precedes overt folate depletion in pregnancy by many weeks and represents another subclinical manifestation of the disease. With folic acid therapy, the observed cytologic alterations may revert to normal in a period of days. It is apparent that squamous cell alterations in vaginal smears of pregnant patients do not necessarily reflect precancerous lesions. The finding of abnormal cytology in pregnancy, while demanding conventional investigation, should suggest the possibility of associated folic acid deficiency. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|