The effects of serum levels, and alterations in the genes of binding protein and receptor of vitamin D on gastric cancer
| Autor: | Soykan Arikan, Arezoo Gheybi, Ozlem Kucukhuseyin, Şermin Durak, Filiz Akyuz, Ilhan Yaylim, Seyda Demirkol, Ş. Ümit Zeybek |
|---|---|
| Přispěvatelé: | Sağlık Hizmetleri Meslek Yüksekokulu |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Vitamin Male medicine.medical_specialty Calcitriol receptor Polymorphism Single Nucleotide 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Stomach Neoplasms Internal medicine Genetics Vitamin D and neurology medicine Humans Genetic Predisposition to Disease Polymorphism Vitamin D Receptor Molecular Biology Gene VDR Sex Characteristics business.industry Binding protein Vitamin D-Binding Protein digestive oral and skin physiology General Medicine Metabolism Middle Aged Gastric Cancer 030104 developmental biology Endocrinology chemistry 030220 oncology & carcinogenesis Case-Control Studies Population study Receptors Calcitriol Female Neoplasm Grading business VDBP |
| Zdroj: | Molecular biology reports. 46(6) |
| ISSN: | 1573-4978 |
| Popis: | Due to many biological cell functions of vitamin D including regulation of cell survival, proliferation and differentiation, the metabolism of itself gains importance in the development of several types of cancer. This case–control study was designed to evaluate the risk of gastric cancer development in terms of VDR rs2228570 & rs731236, and VDBP rs7041 polymorphisms, and serum levels of vitamin D. The study consists of 77 gastric cancer patients and 84 healthy individuals. VDR and VDBP gene polymorphisms and vitamin D levels were determined by using PCR–RFLP and HPLC methods. The distribution of VDR or VDBP gene variants were not different in study groups. The serum level of 25-hydroxyvitamin D was significantly lower in gastric cancer patients versus controls (16 ± 6 → 11 ± 6 ng/ml) in which male patients have higher levels than females. Although the whole study population lacks normal levels of 25-hydroxyvitamin D, it was found that the risk of the development of gastric cancer was approximately fourfold higher in cases with severe vitamin D ( |
| Databáze: | OpenAIRE |
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