Endocrine Therapy in Early Breast Cancer
| Autor: | Elmar Stickeler, Katja Krauss |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
medicine.medical_specialty Aromatase inhibitor business.industry medicine.drug_class medicine.medical_treatment Mortality rate Endocrine therapy Review Article medicine.disease 03 medical and health sciences 0302 clinical medicine Breast cancer 030220 oncology & carcinogenesis Internal medicine medicine Endocrine system Surgery 030212 general & internal medicine business Adjuvant Tamoxifen medicine.drug Early breast cancer |
| Zdroj: | Breast Care (Basel) |
| ISSN: | 1661-3791 |
| Popis: | Background: Endocrine therapy with a standard duration of 5 years is well known as an effective treatment for endocrine-sensitive breast cancer. Summary: In the adjuvant setting this treatment reduces the 15-year mortality rates by about 30 and 40% with tamoxifen and aromatase inhibitor, respectively. The well-known long-term recurrence risk of luminal cancers led to multiple trials examining the benefit of extended endocrine treatment for up to 15 years. Additional benefit with extended therapy was seen for patients with high recurrence risk. Also, additional ovarian suppression for premenopausal women exhibited a significant benefit for patients at higher risk. Key Messages: The data of the last years will be summarized and discussed, also considering the side effects of the different treatment options. |
| Databáze: | OpenAIRE |
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