| Autor: |
Ali Alfaifi, Sana Hosseini, Amir R. Esmaeili, Ross Walenga, Andrew Babiskin, Theodore Schuman, Worth Longest, Michael Hindle, Laleh Golshahi |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
International journal of pharmaceutics. 622 |
| ISSN: |
1873-3476 |
| Popis: |
To improve the relationships between commonly conducted in vitro studies for locally-acting nasal spray drug products with in vivo regional deposition, this study developed a set of in vitro adult nasal geometries that captured the range of nasal drug delivery to the region posterior to internal nasal valve (INV), also known as posterior delivery (PD), and evaluated their performance with existing in vivo data. The PD of fluticasone propionate (FP) and fluticasone furoate (FF) in 40 nasal cavities was statistically analyzed to identify three airway models representing the low, mean, and high PD in adults. The models were also externally validated by comparing the in vitro nasal deposition from a different drug product (mometasone furoate (MF)) with the relevant in vivo data. The three selected geometries represented the low, mean, and high PD with multiple nasal sprays. They were verified in terms of reproducibility of in vitro data and validated by showing a reasonable agreement with preexisting in vivo MF PD despite differences in administration and defining the regions. The three models are envisioned to potentially facilitate the development of locally-acting nasal sprays and provide a better understanding of how in vitro metrics relate to in vivo regional nasal deposition. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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