Myocarditis in systemic lupus erythematosus diagnosed by 18F-fluorodeoxyglucose positron emission tomography
| Autor: | Laura Geraldino-Pardilla, Thania Perez-Recio, Alexandra Perel-Winkler, Afshin Zartoshti, Anca Askanase, Sabahat Bokhari |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Myocarditis Immunology 030204 cardiovascular system & hematology Chest pain Asymptomatic 03 medical and health sciences 0302 clinical medicine Internal medicine medicine 030203 arthritis & rheumatology Co-Morbidities Systemic lupus erythematosus medicine.diagnostic_test biology business.industry General Medicine medicine.disease Troponin Heart failure Cardiology biology.protein Transthoracic echocardiogram medicine.symptom business Electrocardiography |
| Zdroj: | Lupus Science & Medicine |
| ISSN: | 2053-8790 |
| Popis: | Objectives Cardiovascular diseaseand heart failure (CHF) are leading causes of death in systemic lupus erythematosus (SLE). The underlying mechanisms for increased CHF in SLE are unclear but myocardial inflammation and lupus myocarditis (LM) may play a role. We propose that 18F-fluorodeoxyglucose–positron emission tomography (18F-FDG–PET)/CT can help diagnose LM. Methods This report describes eight patients with presumed LM; five patients were evaluated due to active cardiorespiratory symptoms and three patients were participating in a pilot study to determine the prevalence of subclinical myocarditis in SLE. Clinical characteristics, laboratory and cardiac testing including electrocardiography (ECG), transthoracic echocardiogram (TTE), coronary artery evaluation as well as 18F-FDG–PET/CT imaging are discussed. Results Four patients were African American and the others were Hispanic. Half presented with chest pain; 37% had dyspnoea and 25% were asymptomatic. The median SLE Disease Activity Index (SLEDAI-2K) was 5 (2–18) and SLICC Damage Index (SDI) 0.5 (0–5). The median troponin level was 0.08 ng/mL (0–0.9). The most common ECG findings were non-specific ST-T wave abnormalities (n=5). Fifty per cent of the patients had a decreased ejection fraction on TTE and all patients had diffuse myocardial FDG uptake on 18F-FDG–PET/CT consistent with myocardial inflammation. Conclusion This case series is the first to describe the use of 18F-FDG–PET/CT in the diagnosis of LM and discuss the clinical characteristics and cardiac findings of eight patients with LM supporting the role for cardiac 18F-FDG–PET/CT in its diagnosis. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|