A randomised single blind trial of a combined mumps measles rubella vaccine to evaluate serological response and reactions in the UK population
| Autor: | David Hull, C.R. Pullan, S. Edees |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
congenital
hereditary and neonatal diseases and abnormalities Pediatrics medicine.medical_specialty Population Measles Vaccine Mumps Vaccine MMR vaccine complex mixtures Measles Rubella Random Allocation medicine Humans Rubella Vaccine education education.field_of_study Reactogenicity business.industry Public Health Environmental and Occupational Health Infant General Medicine medicine.disease Rash digestive system diseases United Kingdom Vaccination Drug Combinations Immunology Measles vaccine medicine.symptom business Measles-Mumps-Rubella Vaccine |
| Zdroj: | Public health. 105(2) |
| ISSN: | 0033-3506 |
| Popis: | Four hundred and twenty children were randomly assigned to receive either mumps measles rubella (MMR) vaccine (207) or measles vaccine (213) in a single blind study, to investigate the reactogenicity and serology of the MMR vaccine. There was no significant difference between the number of children developing symptoms after MMR vaccination to those developing symptoms after measles vaccination. Both vaccines are associated with a rash, temperature and restlessness five to thirteen days after vaccination. The serological response to measles vaccine was similar in both groups with 92–6% seroconverting with MMR, and 96–8% with measles. Seroconvertion against mumps and rubella with the MMR vaccine was 88% and 96% respectively. This study confirms the safety and efficacy of the MMR vaccine in a UK population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|