Anti-KIR4.1 Antibodies in Chinese Patients with Central Nervous System Inflammatory Demyelinating Disorders
| Autor: | Ailin Tao, Huiming Xu, Shunzhi Zhuang, Cong Gao, Xinguang Yang, Qingmei Huang, Rong Zhong, Linzhan Wu, Junyan Liang, Youming Long |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine Adolescent Immunology Central nervous system Demyelinating Autoimmune Diseases CNS Disease Transfection Young Adult 03 medical and health sciences 0302 clinical medicine Endocrinology Blood serum Asian People medicine Humans Potassium Channels Inwardly Rectifying Child Demyelinating Disorder Aged Autoantibodies Aged 80 and over Aquaporin 4 biology Endocrine and Autonomic Systems business.industry Multiple sclerosis Neuromyelitis Optica Middle Aged medicine.disease HEK293 Cells 030104 developmental biology medicine.anatomical_structure Neurology Neuromyelitis Optica Spectrum Disorders Child Preschool biology.protein Biomarker (medicine) Female Antibody business 030217 neurology & neurosurgery |
| Zdroj: | Neuroimmunomodulation. 23:295-300 |
| ISSN: | 1423-0216 1021-7401 |
| DOI: | 10.1159/000452764 |
| Popis: | Objectives: The aim of this study was to explore the frequency of KIR4.1 antibodies in patients with multiple sclerosis (MS) and in control groups using a cell-based assay. Materials and Methods: A transfected HEK-293A cell line expressing KIR4.1 was established to test for the presence of KIR4.1 antibodies in blood serum. We tested 904 subjects, including 188 patients with MS, 264 patients with neuromyelitis optica spectrum disorders (NMOSD), 209 patients with other inflammatory neurologic disease (OIND), 203 patients with other noninflammatory neurological disease (OND), and 40 healthy controls. Results: KIR4.1 antibodies were present in 23 of the 188 (12.2%) MS patients, 42 of the 264 (15.9%) NMOSD patients, 32 of the 209 (15.3%) OIND patients, 24 of the 203 (11.8%) OND patients, and 2 of the 40 (5%) healthy controls. There were no significant differences among the MS and control groups (p = 0.279). Conclusions: Anti-KIR4.1 antibody, as determined by a cell-based assay, is not a specific biomarker for MS. |
| Databáze: | OpenAIRE |
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