Engine shutdown: Migrastatic strategies and prevention of metastases

Autor:	Martina Raudenská, Kateřina Petrláková, Tamara Juriňáková, Jindřiška Leischner Fialová, Michaela Fojtů, Milan Jakubek, Daniel Rösel, Jan Brábek, Michal Masařík
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	Cancer Research Oncology cell migration nanocarriers migrastatic therapy cancer cancer therapy metastasis mitochondria-targeting therapy
Zdroj:	Trends in Cancer 9(4), 293-308. (2023) Trends in Cancer
Popis:	Most cancer-related deaths among patients with solid tumors are caused by metastases. Migrastatic strategies represent a unique therapeutic approach to prevent all forms of cancer cell migration and invasion. Because the migration machinery has been shown to promote metastatic dissemination, successful migrastatic therapy may reduce the need for high-dose cytotoxic therapies that are currently used to prevent the risk of metastatic dissemination. In this review we focus on anti-invasive and antimetastatic strategies that hold promise for the treatment of solid tumors. The best targets for migrastatic therapy would be those that are required by all forms of motility, such as ATP availability, mitochondrial metabolism, and cytoskeletal dynamics and cell contractility.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74ac0c6d2f94511c47e2363e66af1628 https://hdl.handle.net/20.500.14178/1810 Zobrazit plný text záznamu