High serum chemerin level in CKD patients is related to kidney function, but not to its adipose tissue overproduction

Autor:	Joanna Blaszak, Sławomir Lizakowski, Marek Szolkiewicz, Bolesław Rutkowski, Marcin Konarzewski, Julian Swierczynski, Elzbieta Sucajtys-Szulc
Rok vydání:	2015
Předmět:	Male medicine.medical_specialty medicine.medical_treatment Adipose tissue Adipokine Renal function Critical Care and Intensive Care Medicine Kidney Function Tests Risk Assessment Sensitivity and Specificity Severity of Illness Index Reference Values Renal Dialysis Internal medicine medicine Chemerin Humans Renal replacement therapy Renal Insufficiency Chronic Kidney transplantation Aged Retrospective Studies Aged 80 and over biology business.industry Lipid metabolism General Medicine Middle Aged medicine.disease Prognosis Kidney Transplantation Endocrinology C-Reactive Protein Adipose Tissue Nephrology Case-Control Studies biology.protein Intercellular Signaling Peptides and Proteins Female Hemodialysis Chemokines business Biomarkers
Zdroj:	Renal failure. 37(6)
ISSN:	1525-6049
Popis:	Chemerin is an adipokine modulating inflammatory response and affecting glucose and lipid metabolism. These disturbances are common in CKD. The aim of the study was: (a) to evaluate circulating chemerin level at different stages of CKD; (b) to measure subcutaneous adipose tissue chemerin gene expression; (c) to estimate the efficiency of renal replacement therapy in serum chemerin removal. 187 patients were included into the study: a) 58 patients with CKD; (b) 29 patients on hemodialysis; (c) 20 patients after kidney transplantation. 80 subjects constituted control group. Serum chemerin concentration was estimated by ELISA. The adipose tissue chemerin mRNA level was measured by RT-qPCR. The mean serum chemerin concentration in CKD patients was 70% higher than in the control group (122.9 ± 33.7 vs. 72.6 ± 20.7 ng/mL; p < 0.001) and it negatively correlated with eGFR (r = -0.71, p < 0.001). The equally high plasma chemerin level was found in HD patients and a HD session decreased it markedly (115.7 ± 17.6 vs. 101.5 ± 16.4 ng/mL; p < 0.001). Only successful kidney transplantation allowed it to get down to the values noted in controls (74.8 ± 16.0 vs. 72.6 ± 20.7 ng/mL; n.s.). The level of subcutaneous adipose tissue chemerin mRNA in CKD patients was not different than in patients of the control group. The study demonstrates that elevated serum chemerin concentration in CKD patients: (a) is related to kidney function, but not to increased chemerin production by subcutaneous adipose tissue, and (b) it can be efficiently corrected by hemodialysis treatment and normalized by kidney transplantation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74abff50030eb3bfe81bcb94c300fdc0 https://pubmed.ncbi.nlm.nih.gov/25945605 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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