Tiam1 siRNA enhanced the sensitivity of sorafenib on esophageal squamous cell carcinoma in vivo
| Autor: | Xiaoli Liu, Guirong Shi, Xin Wang, Lifeng Jiang, Huaimin Liu |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Sorafenib
Oncology Male Niacinamide medicine.medical_specialty Proliferation index Esophageal Neoplasms Antineoplastic Agents Apoptosis Mice In vivo Internal medicine Cell Line Tumor medicine Carcinoma Animals Guanine Nucleotide Exchange Factors Humans T-Lymphoma Invasion and Metastasis-inducing Protein 1 RNA Small Interfering neoplasms Mice Inbred BALB C Cell growth Chemistry Phenylurea Compounds RNA General Medicine medicine.disease Xenograft Model Antitumor Assays digestive system diseases Ki-67 Antigen Cell culture Cancer research Carcinoma Squamous Cell Esophageal Squamous Cell Carcinoma Cyclin-Dependent Kinase Inhibitor p27 medicine.drug |
| Zdroj: | Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine. 35(8) |
| ISSN: | 1423-0380 |
| Popis: | Our previous study demonstrated that Tiam1 was highly expressed in esophageal squamous cell carcinoma (ESCC) tissues. In the present study, we investigated the therapeutic role of Tiam1 siRNA in combination with sorafenib in xenografted human ESCC. Our results demonstrated that expression of Tiam1 protein in EC9706 cells was significantly higher than those in ESCC cells (Eca109 and EC1) and normal esophageal epithelial cells Het-1A (P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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