Nucleotide sequence of the Synechococcus sp. PCC7942 Heme gene encoding the homologue of mammalian uroporphyrinogen decarboxylase
| Autor: | A. M. Ten Berge, Gerhardus Venema, J. A. K. W. Kiel |
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| Rok vydání: | 1992 |
| Předmět: |
DNA
Bacterial Uroporphyrinogen III decarboxylase Molecular Sequence Data Biology Cyanobacteria Biochemistry chemistry.chemical_compound Endocrinology Genetics medicine Animals Humans Uroporphyrinogen Decarboxylase Porphyria cutanea tarda Amino Acid Sequence Molecular Biology Peptide sequence Heme Gene chemistry.chemical_classification Base Sequence Sequence Homology Amino Acid Protein primary structure Nucleic acid sequence medicine.disease Molecular biology Amino acid chemistry |
| Zdroj: | DNA Sequence. 2:415-418 |
| ISSN: | 1042-5179 |
| DOI: | 10.3109/10425179209020822 |
| Popis: | We have determined the complete nucleotide sequence of a Synechococcus sp. PCC7942 gene encoding the homologue of mammalian uroporphyrinogen decarboxylase (UROD). The gene, designated hemE, encoded a polypeptide of 354 amino acids with a molecular weight of 39,283. The primary sequences of the polypeptide encoded by hemE and human and rat UROD had 32.5% identical amino acid residues. No invariant cysteine residues were found, despite the fact that UROD isolated from different sources has been shown to be inhibited by sulfhydryl reagents. The knowledge of the primary structure of this cyanobacterial protein may be helpful in better understanding the structural alterations and functional abnormalities of UROD in patients suffering from Porphyria Cutanea Tarda (PCT). |
| Databáze: | OpenAIRE |
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