Ghrelin infused into the dorsomedial hypothalamus of male mice increases food intake and adiposity
| Autor: | Yosra Abdelaziz, Alfonso Abizaid, Su-Bin Park, Lindsay Hyland |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Hypothalamus Adipose tissue Experimental and Cognitive Psychology Eating Mice 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Internal medicine medicine Animals 0501 psychology and cognitive sciences Obesity 050102 behavioral science & comparative psychology Receptors Ghrelin Receptor Respiratory exchange ratio Adiposity 2. Zero hunger business.industry digestive oral and skin physiology 05 social sciences Antagonist Ghrelin Endocrinology medicine.symptom Energy Metabolism business Weight gain hormones hormone substitutes and hormone antagonists 030217 neurology & neurosurgery Hormone |
| Zdroj: | Physiology & Behavior. 220:112882 |
| ISSN: | 0031-9384 |
| DOI: | 10.1016/j.physbeh.2020.112882 |
| Popis: | Ghrelin is a 28 amino acid peptide hormone that targets the brain to promote feeding and adiposity. The ghrelin receptor, the GHSR1a, is expressed within most hypothalamic nuclei, including the DMH, but the role of GHSR1a in this region on energy balance is unknown. In order to investigate whether GHSR1a within the DMH modulate energy balance, we implanted osmotic minipumps filled with saline, ghrelin, or the GHSR1a antagonist JMV2959, and connected it to a cannula aimed unilaterally at the DMH of adult male C57BLJ6 mice and assessed their metabolic profile. We found that chronic infusion of ghrelin in the DMH promoted an increase in caloric intake as well as a decrease in energy expenditure. This translated to an overall increase in weight gain, primarily in the form of adipose tissue in ghrelin treated animals. Further, chronic ghrelin unilateral infusion into the DMH slowed glucose clearance. These results suggest that GHSR in the DMH significantly contribute to the metabolic effects produced by ghrelin. |
| Databáze: | OpenAIRE |
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