Cumulative risk assessment of the exposure to organophosphorus and carbamate insecticides in the Dutch diet
| Autor: | M.T.M. Van Raaij, J.D. van Klaveren, H. van der Voet, Polly Boon |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Carbamate Insecticides Adolescent medicine.medical_treatment RIKILT - Business Unit Veiligheid & Gezondheid mechanism Cumulative Exposure Oxamyl Orange (colour) pcbs Toxicology Risk Assessment chemistry.chemical_compound Eating Organophosphorus Compounds dioxins Medicine Humans Child Acephate Aged Netherlands Aged 80 and over Models Statistical Pesticide residue business.industry Pesticide Residues toxicity Infant Organothiophosphorus Compounds General Medicine Pesticide Middle Aged pesticide-residues Diet PRI Biometris chemistry Child Preschool RIKILT - Business Unit Safety & Health Phosphoramides Female Carbamates business Cumulative risk assessment Food Science |
| Zdroj: | Food and Chemical Toxicology 46 (2008) 9 Food and Chemical Toxicology, 46(9), 3090-3098 |
| ISSN: | 0278-6915 2003-2005 |
| Popis: | We report the acute cumulative exposure to organophosphorus insecticides (OPs) and carbamates in the Dutch population and young children (1-6 years) via the diet. Residue data were derived from Dutch monitoring programmes performed during 2003-2005, and food consumption levels from the Dutch National Food Consumption Survey 1997/1998. The relative potency factor (RPF) approach was used to cumulate the exposure to OPs and carbamates using acephate and oxamyl as index compound respectively. The exposure was estimated using the probabilistic approach, including unit variability and processing effects. We demonstrate that about 3% of the composite samples analysed for OPs and 0.2% for carbamates contain combinations of these pesticides. The P99.9 of exposure to OPs and carbamates in the total Dutch population equals 23 and 0.64microg/kg BW/d respectively. For young children the corresponding exposure levels are 57 and 1.47microg/kg BW/d. When comparing the P99.9 of exposure with the ARfD, 50 and 9microg/kg BW/d for acephate and oxamyl respectively, there is only a possible health risk for young children. Spinach contributed most to the exposure to OPs in both age groups, followed by orange and mandarin. For carbamates apple (sauce) was the main product determining the exposure. |
| Databáze: | OpenAIRE |
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