Unusual Clinical Manifestations and Outcome of Multisystem Inflammatory Syndrome in Children (MIS-C) in a Tertiary Care Hospital of North India
Autor: | Amitabh Singh, Shobhna Gupta Dch, Rani Gera, Ravindra Mohan Pandey, Harish Chellani, Balvinder Singh Arora, Nidhi Chopra |
---|---|
Rok vydání: | 2021 |
Předmět: |
Male
medicine.medical_specialty Pediatrics India MIS-C 030204 cardiovascular system & hematology 03 medical and health sciences 0302 clinical medicine Lower respiratory tract infection Epidemiology medicine Humans Pediatrics Perinatology and Child Health 030212 general & internal medicine Child Original Paper Kawasaki disease business.industry Infant Newborn COVID-19 Infant Odds ratio Prognosis medicine.disease Comorbidity Rash Systemic Inflammatory Response Syndrome toxic shock syndrome Infectious Diseases Child Preschool SARS-CoV2 Pediatrics Perinatology and Child Health Cohort Female medicine.symptom AcademicSubjects/MED00670 business Cohort study |
Zdroj: | Journal of Tropical Pediatrics |
ISSN: | 1465-3664 |
Popis: | Till date, there is paucity of published literature on clinical manifestations of Coronavirus disease 2019 (COVID-19) in children from low-middle-income countries (LMIC). Most of the reports are from Europe, USA or China. Our study aimed to capture data on varied and unusual clinical presentation and management of MIS-C (Multisystem Inflammatory Syndrome in Children) with COVID-19 and compare the MIS-C and non-MIS-C children. This was a single-centre cohort study of 41 COVID positive children 0–12 years age hospitalized between 1 April 2020 and 31 July 2020. Data were entered into standardized WHO Case Report Form and analysed using strata 15.0 statistical software. Twenty out of 41 children fulfilled the criteria of MIS-C. Male-to-female ratio in the cohort was 1.73:1. In MIS-C cases, predominant clinical manifestation was fever (100%), neurological manifestations (80%), lower respiratory tract infection (50%), rash (35%) and acute gastroenteritis (25%). They were categorized into Acute Encephalitis-like illness in 35%, Kawasaki-like disease, Toxic Shock-like syndrome and Comorbidity with systemic complications in 20% each. Ninety percent of MIS-C cases required oxygen supplementation with odds ratio (OR) 18 (3.22–100.48), whereas 65% required mechanical ventilation with OR 37.14 (4.08–338.10). Most of them had raised inflammatory markers and hepatic enzymes derangement. Steroids, Intravenous immunoglobulin and supportive therapy were mainstay of management for MIS-C group. Most MIS-C group children had multisystem involvement with predominant neurological manifestations at time of presentation. Delay in diagnosis and referral may have adversely affected the prognosis and outcome. |
Databáze: | OpenAIRE |
Externí odkaz: |