Nickel-Catalyzed Enantioselective Cross-Coupling of N-Hydroxyphthalimide Esters with Vinyl Bromides
| Autor: | Naoyuki Suzuki, Kelsey E. Poremba, Julie L. Hofstra, Sarah E. Reisman |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Vinyl Compounds
Ethylene chemistry.chemical_element Phthalimides Stereoisomerism 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry Catalysis Article chemistry.chemical_compound Nickel Organic chemistry Physical and Theoretical Chemistry 010405 organic chemistry Chemistry Organic Chemistry Temperature Enantioselective synthesis Esters Oxidation reduction N-hydroxyphthalimide 0104 chemical sciences Functional group Oxidation-Reduction |
| Zdroj: | Organic Letters. 19:2150-2153 |
| ISSN: | 1523-7052 1523-7060 |
| DOI: | 10.1021/acs.orglett.7b00793 |
| Popis: | An enantioselective Ni-catalyzed cross-coupling of N-hydroxyphthalimide esters with vinyl bromides is reported. The reaction proceeds under mild conditions and uses tetrakis(N,N-dimethylamino)ethylene as a terminal organic reductant. Good functional group tolerance is demonstrated, with over twenty examples of reactions that proceed in greater than 90% ee. |
| Databáze: | OpenAIRE |
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