A differential regulatory T cell signature distinguishes the immune landscape of COVID-19 hospitalized patients from those hospitalized with other respiratory viral infections
| Autor: | Joshua T. Schiffer, Martin Prlic, A. J. Konecny, Florian Mair, Evan Greene, Raphael Gottardo, Caitlin R Wolf, Jim Boonyaratanakornkit, Jennifer M. Lund, Marie Frutoso, Helen Y. Chu, Sarah C. Vick, Jennifer Logue |
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| Rok vydání: | 2021 |
| Předmět: |
Chemokine
biology business.industry Regulatory T cell medicine.medical_treatment Immunology SciAdv r-articles Life Sciences Disease Virus Coronavirus Immune system Cytokine medicine.anatomical_structure Pandemic biology.protein Respiratory virus Medicine Biomedicine and Life Sciences business Research Article |
| Zdroj: | Science Advances |
| DOI: | 10.1101/2021.03.25.21254376 |
| Popis: | Description Unique circulating regulatory T cell phenotypes distinguish hospitalized patients with SARS-CoV-2. Despite recent studies of immunity to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), little is known about how the immune response against SARS-CoV-2 differs from other respiratory infections. We compare the immune signature from hospitalized SARS-CoV-2–infected patients to patients hospitalized prepandemic with influenza or respiratory syncytial virus (RSV). Our in-depth profiling indicates that the immune landscape in SARS-CoV-2 patients is largely similar to flu or RSV patients. Unique to patients infected with SARS-CoV-2 who had the most critical clinical disease were changes in the regulatory T cell (Treg) compartment. A Treg signature including increased frequency, activation status, and migration markers was correlated COVID-19 severity. These findings are relevant as Tregs are considered for therapy to combat the severe inflammation seen in COVID-19 patients. Likewise, having defined the overlapping immune landscapes in SARS-CoV-2, existing knowledge of flu and RSV infections could be leveraged to identify common treatment strategies. |
| Databáze: | OpenAIRE |
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