Small amounts of venous gas embolism cause delayed impairment of endothelial function and increase polymorphonuclear neutrophil infiltration
| Autor: | Alf O. Brubakk, Vibeke Nossum, Astrid Hjelde |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Nitroprusside Pathology medicine.medical_specialty Endothelium Neutrophils Physiology Vasodilator Agents Pulmonary Edema Air embolism Physiology (medical) Edema Cell Adhesion medicine Animals Embolism Air Orthopedics and Sports Medicine Dose-Response Relationship Drug Vascular disease business.industry Respiratory disease Public Health Environmental and Occupational Health General Medicine medicine.disease Acetylcholine Vasodilation Endothelial stem cell medicine.anatomical_structure Embolism Extravascular Lung Water Female Endothelium Vascular Rabbits Jugular Veins medicine.symptom business Infiltration (medical) |
| Zdroj: | European Journal of Applied Physiology. 86:209-214 |
| ISSN: | 1439-6327 1439-6319 |
| DOI: | 10.1007/s00421-001-0531-y |
| Popis: | Gas bubbles from decompression and gas embolization lead to endothelial dysfunction and mechanical injury in the pig, rabbit and lamb. In the study presented here, 0.01 ml air/min/kg was infused through a catheter into the jugular vein in 12 rabbits for 60 min. The endothelial response was measured using tension measurements in the blood vessel wall, and morphological changes where quantified using light microscopy and image processing. Percent lung water content was calculated and used to estimate the severity of pulmonary oedema. The infusion led to a significant decrease in the acetylcholine-mediated endothelial-dependent vasodilatation in the pulmonary artery 6 h after the infusion (6-h group, n = 6). A decrease in substance-P-mediated endothelial-dependent vasodilatation was also detected. No changes where seen in a group of rabbits examined 1 h after infusion (l-h group, n=6). The impaired endothelial-dependent vasodilatation caused by the bubbles is probably biochemical in origin, since no visible changes were seen in the endothelial layer. A significant increase in polymorphonuclear neutrophils was observed in the 6-h group compared to the l-h group. This study demonstrates that small numbers of bubbles, corresponding to "silent bubbles", lead to an impairment of the endothelial-dependent vasoactive response. |
| Databáze: | OpenAIRE |
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