Heterotopic ossification in rectal cancer: Rare finding with a novel proposed mechanism

Autor:	Emilie Morphew, Marcia R. Gottfried, Relief Jones, Hilliard F. Seigler, Alan P. Kypson
Rok vydání:	2003
Předmět:	Adult Antimetabolites Antineoplastic Pathology medicine.medical_specialty animal structures Colorectal cancer Bone Morphogenetic Protein 2 Adenocarcinoma Fibroblast growth factor Bone morphogenetic protein Bone morphogenetic protein 2 Transforming Growth Factor beta medicine Rectal Adenocarcinoma Humans Enzyme Inhibitors Uracil Colectomy Rectal Neoplasms Ossification business.industry Ossification Heterotopic General Medicine medicine.disease Immunohistochemistry Neoadjuvant Therapy Treatment Outcome Oncology Bone Morphogenetic Proteins embryonic structures Female Fibroblast Growth Factor 2 Radiotherapy Adjuvant Surgery Heterotopic ossification Fluorouracil medicine.symptom business
Zdroj:	Journal of Surgical Oncology. 82:132-136
ISSN:	1096-9098 0022-4790
Popis:	The rare finding of heterotopic ossification in a case of primary rectal adenocarcinoma is described along with a review of the literature. Immunohistochemistry for a bone morphogenic protein (BMP-2) and fibroblast growth factor (FGF-2), both of which induce and stimulate bone formation, was performed and revealed overexpression of BMP-2 by the tumor cells, elucidating a possible mechanism which up to now had been based merely on speculation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74a46b9dd991b53369b9683f70ba6654 https://doi.org/10.1002/jso.10181 Zobrazit plný text záznamu Plný text