RNA Polymerase Collision versus DNA Structural Distortion: Twists and Turns Can Cause Break Failure
| Autor: | Nicholas R. Pannunzio, Michael R. Lieber |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
DNA
Bacterial 0301 basic medicine Transcription Genetic DNA damage Biology Article 03 medical and health sciences chemistry.chemical_compound Transcription (biology) Chromosomal Instability Neoplasms Chromosome instability RNA polymerase Genetic model Animals Humans DNA Fungal Molecular Biology Polymerase Genetics Models Genetic RNA DNA DNA-Directed RNA Polymerases Cell Biology Cell Transformation Neoplastic 030104 developmental biology chemistry biology.protein Nucleic Acid Conformation DNA Damage |
| Zdroj: | Molecular Cell. 62:327-334 |
| ISSN: | 1097-2765 |
| Popis: | The twisting of DNA due to the movement of RNA polymerases is the basis of numerous classic experiments in molecular biology. Recent mouse genetic models indicate that chromosomal breakage is common at sites of transcriptional turbulence. Two key studies on this point mapped breakpoints to sites of either convergent or divergent transcription but arrived at different conclusions as to which is more detrimental and why. The issue hinges on whether DNA strand separation is the basis for the chromosomal instability or collision of RNA polymerases. |
| Databáze: | OpenAIRE |
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