High levels of IL-10 and determination of other cytokines and chemokines in HIV-associated haemophagocytic syndrome
| Autor: | Olivier Benveniste, C. Leport, J.‐L. Vildé, Nathalie Dereuddre-Bosquet, P. Clayette, Dominique Dormont |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Adult
Receptors CXCR4 Chemokine Histiocytosis Non-Langerhans-Cell Receptors CCR5 medicine.medical_treatment T cell Immunology HIV Infections Peripheral blood mononuclear cell Interferon-gamma Chemokine receptor Immune system Proviruses Humans Immunology and Allergy Medicine RNA Messenger Chemokine CCL4 Chemokine CCL5 Macrophage inflammatory protein Chemokine CCL3 biology Tumor Necrosis Factor-alpha business.industry Interleukins Immunity to Infection Macrophage Inflammatory Proteins Interleukin-10 Interleukin 10 Cytokine medicine.anatomical_structure DNA Viral HIV-1 biology.protein Cytokines RNA Viral Female Chemokines business |
| Zdroj: | Clinical and Experimental Immunology. 121:320-323 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1046/j.1365-2249.2000.01288.x |
| Popis: | SUMMARY Haemophagocytic syndrome (HPS) and HIV infection are both associated with cytokine network dysregulation. We therefore analysed plasma levels and mRNA synthesis in peripheral blood mononuclear cells (PBMC) of cytokines, chemokines and chemokine receptors in one HIV-infected patient with HPS. We compared the results with those for eight HIV-infected patients with similar CD4+ T cell counts (207/mm3versus controls: median 214/mm3) and plasma virus load (4·1 log copies/ml, versus controls: median 4·2 log copies/ml). The HPS patient had a lower viral DNA load in PBMC and higher plasma levels of interferon-gamma, IL-10, and macrophage inflammatory protein (MIP)-1β. No difference in plasma tumour necrosis factor-alpha (TNF-α), IL-6 and MIP-1α concentration was observed between the HPS patient and control patients. No difference was observed in TNF-α, IL-1β, IL-10, IL-4, MIP-1α, MIP-1β, RANTES, CXCR-4, and CCR-5 mRNA levels in PBMC, but IL-6 levels were higher in the HPS patient. Our results emphasize the role of IL-10 in the control of immune hyperactivation that is observed in HPS. |
| Databáze: | OpenAIRE |
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