Medically Controlled Glaucoma Patients Show Greater Increase in Intraocular Pressure than Surgically Controlled Patients with the Water Drinking Test
| Autor: | Helen V. Danesh-Meyer, Taras Papchenko, Yu-whee Tan, Greg D. Gamble |
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| Rok vydání: | 2008 |
| Předmět: |
Male
Alkylating Agents medicine.medical_specialty Intraocular pressure genetic structures Post hoc Mitomycin Eye disease medicine.medical_treatment Drinking Vision Disorders Glaucoma Ocular hypertension Trabeculectomy Diagnostic Techniques Ophthalmological Ophthalmology medicine Humans Prospective Studies Antihypertensive Agents Intraocular Pressure Aged business.industry Outcome measures Water medicine.disease Combined Modality Therapy eye diseases Water drinking test Female sense organs Visual Fields business Glaucoma Open-Angle |
| Zdroj: | Ophthalmology. 115:1566-1570 |
| ISSN: | 0161-6420 |
| DOI: | 10.1016/j.ophtha.2008.01.023 |
| Popis: | Purpose To evaluate whether patients who have undergone trabeculectomy with mitomycin C have a different intraocular pressure (IOP) response profile after the water drinking test (WDT) from that of patients who are medically managed with a similar baseline IOP and level of visual field (VF) damage. Design Prospective observational study. Participants Thirty glaucoma patients with IOP controlled by trabeculectomy and 30 with medically treated glaucoma matched for level of VF damage and IOP at baseline (7–14 mmHg). Methods All patients underwent the WDT, which involved drinking 1000 ml of water in 15 minutes. Main Outcome Measures The IOP was measured before the WDT and subsequently at 15-minute intervals for 1 hour. The peak IOP with the WDT was compared between both groups using Tukey post hoc multiple comparison and paired t tests. Results Baseline IOPs were 10.4±2.3 mmHg in surgically treated and 11.1±1.8 mmHg ( P = 0.07) in medically treated eyes. After the WDT, mean IOPs in the surgically and medically treated groups were 10.7±2.3 mmHg and 14.6±2.2 mmHg. Mean maximum IOPs were 11.7±2.6 mmHg and 17.3±2.7 mmHg in the surgically and medically treated groups, respectively ( P P Conclusions Patients with advanced glaucoma who are medically controlled show greater IOP elevation and peak IOP after the WDT than eyes that have undergone trabeculectomy. Financial Disclosure(s) The authors have no proprietary or commercial interest in any materials discussed in this article. |
| Databáze: | OpenAIRE |
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