Novel glycosidase inhibitors, nojirimycin B and D-mannonic-.DELTA.-lactam. Isolation, structure determination and biological property

Autor: Yoshio Kodama, Takashi Tsuruoka, Shigeharu Inouye, Taro Niida, Yasuaki Ogawa, Jiro Itoh, Yujiro Yamada, Misao Nobe, Hitoshi Goi, Tomizo Niwa
Rok vydání: 1984
Předmět:
Zdroj: The Journal of Antibiotics. 37:1579-1586
ISSN: 1881-1469
0021-8820
DOI: 10.7164/antibiotics.37.1579
Popis: A new aminosugar named nojirimycin B (1) has been isolated as its bisulfite adduct from the culture broth of Streptomyces lavendulae SF-425, together with nojirimycin. Microbiological oxidation of 1 with Gluconobacter suboxydans IAM 1829 gave a delta-lactam (2). The structures of 1 and 2 were determined to be 5-amino-5-deoxy-D-mannopyranose and D-mannonic-delta-lactam, respectively, on the basis of 1H NMR spectroscopy and X-ray structural analysis. Both 1 and 2 exhibited powerful inhibitory activity against rat epididymal alpha-mannosidase and apricot beta-glucosidase.
Databáze: OpenAIRE
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