The effect of sertindole on QTD and TPTE

Autor:	Johannes J. Struijk, Mads Peter Andersen, Thomas Bork Hardahl, Jørgen K. Kanters, Jimmi Nielsen, J. Dybbro, Egon Toft, Jonathan M. Meyer, Claus Graff
Rok vydání:	2010
Předmět:	Adult Male Indoles Heart disease Denmark Torsades de pointes QT interval Sudden death Electrocardiography Safety-Based Drug Withdrawals Sertindole Heart Rate Torsades de Pointes medicine Humans cardiovascular diseases Prospective Studies Risk factor QTcF Prolongation Imidazoles Cardiac arrhythmia Signal Processing Computer-Assisted Middle Aged medicine.disease Psychiatry and Mental health Long QT Syndrome Anesthesia cardiovascular system Schizophrenia Female Psychology medicine.drug Antipsychotic Agents
Zdroj:	Nielsen, J, Andersen, M P, Graff, C, Kanters, J K, Hardahl, T B, Dybbro, J, Struijk, J, Meyer, J M & Toft, E 2010, ' The effect of sertindole on QTD and TPTE ', Acta Psychiatrica Scandinavica, vol. 121, no. 5, pp. 385-388 . https://doi.org/10.1111/j.1600-0447.2009.01534.x Nielsen, J, Andersen, M P, Graff, C, Kanters, J K, Hardahl, T, Dybbro, J, Struijk, J J, Meyer, J M & Toft, E 2010, ' The effect of sertindole on QTD and TPTE ', Acta Psychiatrica Scandinavica, vol. 121, no. 5, pp. 385-8 . https://doi.org/10.1111/j.1600-0447.2009.01534.x
ISSN:	1600-0447
DOI:	10.1111/j.1600-0447.2009.01534.x
Popis:	Udgivelsesdato: 2010 Nielsen J, Andersen MP, Graff C, Kanters JK, Hardahl T, Dybbro J, Struijk JJ, Meyer JM, Toft E. The effect of sertindole on QTD and TPTE. Objective: Recent research suggests that other surrogate markers than QTc, including QTc dispersion and Tpeak-Tend, may better correlate with cardiac arrhythmia risk. While sertindole significantly prolongs the QTc interval, the effects on other markers of arrhythmia risk, such as QTc dispersion and Tpeak-Tend are unknown. Method: Digital 12-lead ECG was recorded at baseline and at steady-state in 37 patients switched to sertindole. ECG was analysed for Fridericia-corrected QT duration (QTcF), QT dispersion and Tpeak-Tend. Results: From a baseline QTcF of 407 +/- 22 ms, mean QTcF prolongation during sertindole treatment was 20 +/- 23 ms, P < 0.01. No effect on QTc dispersion was found (-1 +/- 11 ms; P = 0.41). No increased duration of the Tpeak-Tend interval from baseline was found (+7 +/- 21 ms; P = 0.05). Conclusion: These findings might be related to the absence of confirmed Torsade de Pointes (TdP) cases related to sertindole exposure, despite sertindole's QTc prolonging effects.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::749e1b10915d602494f548a739661956 https://pubmed.ncbi.nlm.nih.gov/20085555 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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