Trends in the Nontuberculous Mycobacterial Disease Mortality Rate in Japan: A Nationwide Observational Study, 1997–2016
| Autor: | Mitsunobu R. Kano, Toshihiro Koyama, Tomoko Funahashi, Fumio Otsuka, Hideharu Hagiya, Ko Harada |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Microbiology (medical) nontuberculous mycobacteria Aging Population ageing medicine.medical_specialty Tuberculosis Mycobacterium Infections Nontuberculous 03 medical and health sciences 0302 clinical medicine Japan Humans Medicine 030212 general & internal medicine Aged biology business.industry Incidence Public health Incidence (epidemiology) Mortality rate medicine.disease biology.organism_classification Confidence interval Infectious Diseases 030228 respiratory system Female Observational study Nontuberculous mycobacteria trend analysis business Demography |
| Zdroj: | Clinical Infectious Diseases. 73(2):E321-E326 |
| ISSN: | 1058-4838 |
| Popis: | Background The incidence of nontuberculous mycobacterial (NTM) infections has been increasing worldwide, becoming a significant healthcare burden especially among elderly people. This study aimed to evaluate the trends in NTM-associated mortality in Japan. Methods This study used vital statistics data and data on all NTM-associated deaths (N = 18 814) among individuals aged ≥40 years in Japan from 1997 to 2016. We calculated the crude and age-adjusted mortality rates by age and sex and used joinpoint regression to analyze trends and estimate the average annual percentage change (AAPC). We compared crude NTM- and tuberculosis-associated mortality rates by sex. Results The overall crude annual mortality rate increased from 0.63/100 000/year in 1997 to 1.93/100 000/year in 2016 and was the highest among individuals aged 80–84 years. The AAPC of the crude mortality rates among men of all ages and women aged 40–59 years were stable but increased among women aged 60–79 years (3.5%; 95% confidence interval [CI], 2.8–4.3) and ≥80 years (4.3%; 95% CI, 3.7–4.9). Among men, the age-adjusted mortality rates did not show a significant trend, while among women, the rates increased over the study period (AAPC, 4.6%; 95% CI, 2.7–6.6). In women, the crude NTM-associated mortality rate exceeded the tuberculosis mortality rate in 2014, 2015, and 2016. Conclusions NTM mortality increased in Japan between 1997 and 2016, especially among the elderly female population. Given the increasing NTM-associated mortality and the susceptible aging population, public health authorities in Japan should pay greater attention to NTM infections. |
| Databáze: | OpenAIRE |
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