Natural and Natural-like Phenolic Inhibitors of Type B Trichothecene in Vitro Production by the Wheat (Triticum sp.) Pathogen Fusarium culmorum
| Autor: | Angela Fadda, Maria Antonietta Dettori, Giovanna Pani, Barbara Scherm, Roberto Dallocchio, Quirico Migheli, Davide Fabbri, Alessandro Dessì, Emanuela Azara, Virgilio Balmas, Zahra Jahanshiri, Paola Carta, Giovanna Delogu |
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| Rok vydání: | 2014 |
| Předmět: |
Antioxidant
medicine.medical_treatment Trichothecene deoxynivalenol antioxidant activity phenolic inhibitors medicine.disease_cause Microbiology chemistry.chemical_compound Fusarium Phenols Biosynthesis fungicide medicine Fusarium culmorum Pathogen Triticum Plant Diseases biology Toxin General Chemistry Mycotoxins biology.organism_classification Magnolol Fungicides Industrial Fungicide Fusarium head blight chemistry Trichothecenes General Agricultural and Biological Sciences |
| Zdroj: | Journal of agricultural and food chemistry 62 (2014): 4969–4978. doi:10.1021/jf500647h info:cnr-pdr/source/autori:Pani G.; Scherm B.; Azara E.; Balmas V.; Jahanshiri Z.; Carta P.; Fabbri D.; Dettori M.A.; Fadda A.; Dessi A.; Dallocchio R.; Migheli Q.; Delogu G./titolo:Natural and natural-like phenolic inhibitors of type B trichothecene in vitro production by the wheat (Triticum sp.) pathogen Fusarium culmorum/doi:10.1021%2Fjf500647h/rivista:Journal of agricultural and food chemistry/anno:2014/pagina_da:4969/pagina_a:4978/intervallo_pagine:4969–4978/volume:62 |
| ISSN: | 1520-5118 0021-8561 |
| Popis: | Fusarium culmorum, a fungal pathogen of small grain cereals, produces 4-deoxynivalenol and its acetylated derivatives that may cause toxicoses on humans or animals consuming contaminated food or feed. Natural and natural-like compounds belonging to phenol and hydroxylated biphenyl structural classes were tested in vitro to determine their activity on vegetative growth and trichothecene biosynthesis by F. culmorum. Most of the compounds tested at 1.5 or 1.0 mM reduced 3-acetyl-4-deoxynivalenol production by over 70% compared to the control, without affecting fungal growth significantly. Furthermore, several compounds retained their ability to inhibit toxin in vitro production at the lowest concentrations of 0.5 and 0.25 mM. Magnolol 27 showed fungicidal activity even at 0.1 mM. No linear correlation was observed between antioxidant properties of the compounds and their ability to inhibit fungal growth and mycotoxigenic capacity. A guaiacyl unit in the structure may play a key role in trichothecene inhibition. © 2014 American Chemical Society. |
| Databáze: | OpenAIRE |
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