Dietary restriction and the transcription factor clock delay eye aging to extend lifespan in Drosophila Melanogaster
| Autor: | Brian A. Hodge, Geoffrey T. Meyerhof, Subhash D. Katewa, Ting Lian, Charles Lau, Sudipta Bar, Nicole Y. Leung, Menglin Li, David Li-Kroeger, Simon Melov, Birgit Schilling, Craig Montell, Pankaj Kapahi |
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| Rok vydání: | 2022 |
| Předmět: |
Aging
Multidisciplinary 1.1 Normal biological development and functioning Longevity Neurosciences General Physics and Astronomy General Chemistry Eye General Biochemistry Genetics and Molecular Biology Circadian Rhythm Drosophila melanogaster Gene Expression Regulation Underpinning research Genetics Animals Drosophila Proteins Sleep Research Eye Disease and Disorders of Vision Transcription Factors Nutrition |
| Zdroj: | Nature communications, vol 13, iss 1 |
| Popis: | Many vital processes in the eye are under circadian regulation, and circadian dysfunction has emerged as a potential driver of eye aging. Dietary restriction is one of the most robust lifespan-extending therapies and amplifies circadian rhythms with age. Herein, we demonstrate that dietary restriction extends lifespan in Drosophila melanogaster by promoting circadian homeostatic processes that protect the visual system from age- and light-associated damage. Altering the positive limb core molecular clock transcription factor, CLOCK, or CLOCK-output genes, accelerates visual senescence, induces a systemic immune response, and shortens lifespan. Flies subjected to dietary restriction are protected from the lifespan-shortening effects of photoreceptor activation. Inversely, photoreceptor inactivation, achieved via mutating rhodopsin or housing flies in constant darkness, primarily extends the lifespan of flies reared on a high-nutrient diet. Our findings establish the eye as a diet-sensitive modulator of lifespan and indicates that vision is an antagonistically pleiotropic process that contributes to organismal aging. |
| Databáze: | OpenAIRE |
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