T lymphocyte subset profile and serum alpha-1-antitrypsin in pathogenesis of chronic obstructive pulmonary disease
| Autor: | Rajesh Dabur, Manish Kumar, Vibha Yadav, Vijay Kumar Gupta, M. A. Qadar Pasha, D. Chattopadhaya, Gopi Sharma, D. P. Bhadoria, Jyotsana Gupta |
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| Rok vydání: | 2007 |
| Předmět: |
Male
medicine.medical_specialty Translational Studies Immunology CD4-CD8 Ratio Alpha (ethology) Pathogenesis Mice Pulmonary Disease Chronic Obstructive T-Lymphocyte Subsets Internal medicine medicine Immunology and Allergy Animals Humans Lymphocyte Count Aged COPD Mice Inbred BALB C business.industry Respiratory disease Smoking T lymphocyte Middle Aged Trypsin medicine.disease respiratory tract diseases CD4 Lymphocyte Count Endocrinology alpha 1-Antitrypsin Female business CD8 medicine.drug |
| Zdroj: | Clinical and experimental immunology. 149(3) |
| ISSN: | 0009-9104 |
| Popis: | Summary Chronic obstructive pulmonary disease (COPD) is an inflammatory disorder characterized by the presence of non-fully reversible airflow limitation. The study was undertaken to investigate the involvement of alpha-1-antitrypsin (α1AT) and T lymphocyte subsets in the pathogenesis of COPD. Blood samples of 50 subjects, including 25 healthy volunteers and 25 patients with COPD, were analysed. Serum trypsin inhibitory capacity (STIC) was determined by enzymatic assay. CD4+ and CD8+ T lymphocytes were enumerated in heparinized blood using a fluorescence activated cell sorter counter. The STIC in COPD patients was found to be decreased significantly than in controls (P |
| Databáze: | OpenAIRE |
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