Bronchoalveolar inflammation following airway infection in preterm infants with chronic lung disease

Autor: Christian P. Speer, Bettina Götze-Speer, Hartmut Stützer, Peter Groneck, Julia Schmale, Volker Soditt
Rok vydání: 2001
Předmět:
Pulmonary and Respiratory Medicine
Lung Diseases
Male
congenital
hereditary
and neonatal diseases and abnormalities
medicine.medical_treatment
medicine.disease_cause
medicine
Humans
Infant
Very Low Birth Weight
Prospective Studies
Respiratory Tract Infections
Mechanical ventilation
Cross Infection
Respiratory tract infections
medicine.diagnostic_test
business.industry
Ureaplasma infection
Ureaplasma Infections
Respiratory disease
Interleukin-8
Infant
Newborn
Pneumonia
respiratory system
medicine.disease
Respiration
Artificial
respiratory tract diseases
Trachea
Perinatal Care
Bronchoalveolar lavage
Bronchopulmonary dysplasia
Pediatrics
Perinatology and Child Health
Immunology
Immunoglobulin A
Secretory
Female
Inflammation Mediators
Airway
business
Infant
Premature
Ureaplasma urealyticum
Interleukin-1
Zdroj: Pediatric pulmonology. 31(5)
ISSN: 8755-6863
Popis: Chronic lung disease (CLD) of the newborn is associated with pulmonary inflammation. However, the origin of this inflammation is not known. We evaluated the impact of airway infection on bronchoalveolar inflammation in mechanically ventilated preterm infant at risk for CLD (n = 68). Mean and maximum concentrations of the inflammatory mediators (IM) interleukin-1 and interleukin-8 were assayed in the tracheobronchial aspirate fluid (TAF) of neonates with perinatal airway infection (Ureaplasma urealyticum, or bacteria), postnatal nosocomial airway infection, or respiratory disease without airway infection from days 1-10 of postnatal age. Patients with CLD (n = 23;) exhibited increased levels of IM in TAF compared to neonates without CLD. Within the three subgroups, concentrations of IM were increased in CLD patients with perinatal infection and in CLD patients with respiratory disease without airway infection, but not in CLD patients with nosocomial airway infection. Although airway colonization with Gram-negative bacteria was more frequently found in CLD patients within the first month of life, there were no differences between levels of IM in patients colonized with Gram-negative bacteria or coagulase-negative staphyloccoci. We conclude that perinatal infections with Ureaplasma urealyticum or bacteria and respiratory disease without infection, but not nosocomial airway infection, contribute to the bronchopulmonary inflammatory response in neonates with CLD.
Databáze: OpenAIRE
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