Pituitary-ovarian axis during lactational amenorrhoea. I. Longitudinal assessment of follicular growth, gonadotrophins, sex steroids and inhibin levels before and after recovery of menstrual cyclicity
| Autor: | Horacio B. Croxatto, Stella Campo, R.V. Trigo, Ethel V. Velasquez, S. Creus |
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| Rok vydání: | 2005 |
| Předmět: |
endocrine system
medicine.medical_specialty medicine.drug_class media_common.quotation_subject Ovary Biology Ovarian Follicle Internal medicine Follicular phase medicine Humans Lactation Inhibins Longitudinal Studies Ovarian follicle Gonadal Steroid Hormones Amenorrhea Menstrual cycle Menstrual Cycle media_common Ultrasonography Rehabilitation Postpartum Period Obstetrics and Gynecology Prolactin Endocrinology medicine.anatomical_structure Reproductive Medicine Pituitary Gland Gonadotropins Pituitary Female medicine.symptom Gonadotropin Postpartum period Gonadotropins |
| Zdroj: | Human reproduction (Oxford, England). 21(4) |
| ISSN: | 0268-1161 |
| Popis: | BACKGROUND: Comparisons of follicular development and hormonal profile in the same women during and after lactational amenorrhoea (LA) are scarce. We report follicular growth, pituitary and ovarian hormone serum levels in the same women during LA and in follicular phases after resumption of menstrual cyclicity. METHODS: Serum samples were obtained from 10 women during LA between days 60 and 89 post-partum and between days 1 and 4 (early follicular phase; EFP) and 7 and 10 (mid-follicular phase; MFP) of the second and third cycles after LA. RESULTS: The number of follicles >3 mm and diameter of the largest follicle were significantly higher during LA when compared to EFP and MFP. Serum levels of inhibin B were similar in LA and EFP and increased significantly in MFP. Pro-alphaC was significantly higher in EFP than in LA and MFP. Estradiol was similar during all stages. In comparison with EFP and MFP, LA is associated with higher prolactin levels, normal or slightly elevated gonadotrophins and increased number and size of follicles without a parallel increase in estradiol, inhibin B and Pro-alphaC. CONCLUSIONS: During LA, there is a profound dissociation between follicular growth and follicular endocrine activity, which suggests an alteration in the stimulus-response relationship at the follicular level. |
| Databáze: | OpenAIRE |
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