Quantitative analysis of pharmaceuticals in biological fluids using high-performance liquid chromatography coupled to mass spectrometry: a review
| Autor: | David N. Mallett, R. A. Biddlecombe, S. Pleasance, Gordon J. Dear, Robert S. Plumb, David Higton |
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| Rok vydání: | 2001 |
| Předmět: |
Pharmacology
Monolithic HPLC column Chromatography Chemistry Health Toxicology and Mutagenesis Robotics General Medicine Toxicology Mass spectrometry Biochemistry High-performance liquid chromatography Mass Spectrometry Biological fluid Body Fluids Pharmaceutical Preparations Biological fluids Animals Humans Sample preparation Quantitative analysis (chemistry) Chromatography High Pressure Liquid |
| Zdroj: | Xenobiotica. 31:599-617 |
| ISSN: | 1366-5928 0049-8254 |
| DOI: | 10.1080/00498250110060941 |
| Popis: | 1. The development of bio-analysis of drug molecules over the last 10 years is reviewed, focusing on advances in sample preparation, liquid chromatography and detection. 2. Developments have led to improvements in detection sensitivity, enhancements in specificity and increased capacity. 3. Emerging technologies such as monolithic column chromatography and miniaturized chip-based systems are discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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