UnPAXing the Divergent Roles of PAX2 and PAX8 in High-Grade Serous Ovarian Cancer
| Autor: | Amrita Salvi, Laura R. Hardy, Joanna E. Burdette |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Cancer Research animal structures endocrine system diseases Ovary Review Biology lcsh:RC254-282 03 medical and health sciences 0302 clinical medicine medicine Transcription factor fallopian tube PAX2 urogenital system Cancer high-grade serous ovarian carcinoma (HGSC) cell of origin medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens PAX8 female genital diseases and pregnancy complications 3. Good health Serous fluid 030104 developmental biology medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis Cancer research ovary Stem cell Ovarian cancer Fallopian tube |
| Zdroj: | Cancers, Vol 10, Iss 8, p 262 (2018) Cancers |
| ISSN: | 2072-6694 |
| Popis: | High-grade serous ovarian cancer is a deadly disease that can originate from the fallopian tube or the ovarian surface epithelium. The PAX (paired box) genes PAX2 and PAX8 are lineage-specific transcription factors required during development of the fallopian tube but not in the development of the ovary. PAX2 expression is lost early in serous cancer progression, while PAX8 is expressed ubiquitously. These proteins are implicated in migration, invasion, proliferation, cell survival, stem cell maintenance, and tumor growth. Hence, targeting PAX2 and PAX8 represents a promising drug strategy that could inhibit these pro-tumorigenic effects. In this review, we examine the implications of PAX2 and PAX8 expression in the cell of origin of serous cancer and their potential efficacy as drug targets by summarizing their role in the molecular pathogenesis of ovarian cancer. |
| Databáze: | OpenAIRE |
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