Pneumocystis carinii pneumonia in patients with Diamond-Blackfan anemia receiving high-dose corticosteroids
| Autor: | Winston W. Huh, Joan Gill, Sujit Sheth, George R. Buchanan |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Antifungal Agents Anemia Methylprednisolone Immunocompromised Host Fatal Outcome Anti-Infective Agents Prednisone hemic and lymphatic diseases Trimethoprim Sulfamethoxazole Drug Combination medicine Humans Diamond–Blackfan anemia Glucocorticoids Pentamidine Anemia Diamond-Blackfan business.industry Sulfamethoxazole Pneumonia Pneumocystis Infant Hematology medicine.disease Trimethoprim respiratory tract diseases Surgery Pneumonia Oncology Pneumocystis carinii Pediatrics Perinatology and Child Health Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Journal of pediatric hematology/oncology. 24(5) |
| ISSN: | 1077-4114 |
| Popis: | The authors describe three infants with Diamond-Blackfan anemia receiving corticosteroids who were diagnosed with Pneumocystis carinii pneumonia. Two patients exhibited intermittent neutropenia as well. Each child had been receiving relatively high doses of corticosteroids for at least 2 months, and two were having prednisone tapered when pneumonia developed. One child responded to trimethoprim/sulfamethoxazole and pentamidine, but the other two patients died. Infants with Diamond-Blackfan anemia receiving prolonged corticosteroid therapy should receive P. carinii pneumonia prophylaxis, such as trimethoprim/sulfamethoxazole, and prophylaxis should continue during corticosteroid tapering. |
| Databáze: | OpenAIRE |
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