Use of Electronic Health Records to Identify Exposure-Response Relationships in Critically Ill Children: An Example of Midazolam and Delirium
| Autor: | Chani Traube, Michael Cohen-Wolkowiez, Tracy Spears, Kevin M. Watt, Marjan Cobbaert, Felix Boakye-Agyeman, Kanecia O. Zimmerman, P. Brian Smith, Huali Wu, Mara L. Becker, Daniel K. Benjamin |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Critically ill business.industry Exposure response relationships Health records Critical Care and Intensive Care Medicine 030226 pharmacology & pharmacy 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Pediatrics Perinatology and Child Health medicine Midazolam Delirium medicine.symptom business Intensive care medicine medicine.drug |
| Zdroj: | J Pediatr Intensive Care |
| Popis: | Adverse drug events are common in critically ill children and often result from systemic or target organ drug exposure. Methods of drug dosing and titration that consider pharmacokinetic alterations may improve our ability to optimally dose critically ill patients and reduce the risk for drug-related adverse events. To demonstrate this possibility, we explored the exposure-response relationship between midazolam and delirium in critically ill children. We retrospectively examined electronic health records (EHRs) of critically ill children |
| Databáze: | OpenAIRE |
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