Dietary supplementation with n-3 fatty acids increases gluconeogenesis from glycerol but not hepatic glucose production in patients with non-insulin-dependent diabetes mellitus
| Autor: | I Puhakainen, I Ahola, Hannele Yki-Järvinen |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Glycerol
Male medicine.medical_specialty 030309 nutrition & dietetics Medicine (miscellaneous) 030209 endocrinology & metabolism Biology Carbohydrate metabolism 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Double-Blind Method Internal medicine Fatty Acids Omega-3 medicine Lipolysis Humans Plant Oils Beta oxidation Olive Oil 2. Zero hunger chemistry.chemical_classification 0303 health sciences Nutrition and Dietetics Cross-Over Studies Triglyceride Gluconeogenesis nutritional and metabolic diseases Fatty acid Calorimetry Indirect Middle Aged Fish oil 3. Good health Endocrinology Glucose chemistry Diabetes Mellitus Type 2 Liver Female Cholesterol Esters Corn Oil Energy Metabolism Polyunsaturated fatty acid |
| Zdroj: | The American journal of clinical nutrition. 61(1) |
| ISSN: | 0002-9165 |
| Popis: | Fish-oil supplementation decreases serum triacylglycerols but may worsen hyperglycemia in patients with non-insulin-dependent diabetes mellitus. The reason for the possible deterioration of glycemia is unclear. We examined whether inhibition of triacylglycerol synthesis by n-3 fatty acids changes lipolysis, glycerol gluconeogenesis, or fatty acid oxidation. Nine obese patients with non-insulin-dependent diabetes mellitus participated in a randomized double-blind crossover study in which 6 wk of n-3 fatty acid supplementation (12 g fish oil) was compared with 6 wk of corn plus olive oil. Serum triacylglycerols decreased by 30% during n-3 fatty acid supplementation. Glycerol gluconeogenesis ([U-14C]glycerol) increased by 32%. However, overall glucose production ([3-3H]glucose), glycemic control, and fatty acid oxidation remained unchanged. Thus, 6 wk of n-3 fatty acid supplementation lowers triacylglycerols in patients with non-insulin-dependent diabetes mellitus without worsening glycemic control. However, n-3 fatty acid supplementation increases glycerol gluconeogenesis, which could contribute to deterioration of glycemic control during long-term treatment with high doses of fish-oil supplements. |
| Databáze: | OpenAIRE |
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